Cycling Europe<p><a href="https://www.cyclingeu.com/551627/%e2%9a%a0%ef%b8%8f-hit-the-uk-speed-limits-%e2%9a%a0%ef%b8%8f-on-a-bicycle-%f0%9f%9a%b2/" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">cyclingeu.com/551627/%e2%9a%a0</span><span class="invisible">%ef%b8%8f-hit-the-uk-speed-limits-%e2%9a%a0%ef%b8%8f-on-a-bicycle-%f0%9f%9a%b2/</span></a> ⚠️ Hit The UK SPEED LIMITS? ⚠️ ON A BICYCLE? 🚲 <a href="https://pubeurope.com/tags/Bicycle" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Bicycle</span></a> <a href="https://pubeurope.com/tags/Bicycling" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Bicycling</span></a> <a href="https://pubeurope.com/tags/BicyclingUK" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>BicyclingUK</span></a> <a href="https://pubeurope.com/tags/Bike" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Bike</span></a> <a href="https://pubeurope.com/tags/BikeShort" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>BikeShort</span></a> <a href="https://pubeurope.com/tags/BikeSpeeding" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>BikeSpeeding</span></a> <a href="https://pubeurope.com/tags/bikes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bikes</span></a> <a href="https://pubeurope.com/tags/Biking" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Biking</span></a> <a href="https://pubeurope.com/tags/Cycling" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Cycling</span></a> <a href="https://pubeurope.com/tags/cyclist" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>cyclist</span></a> <a href="https://pubeurope.com/tags/gc21s" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>gc21s</span></a> <a href="https://pubeurope.com/tags/GCN" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>GCN</span></a> <a href="https://pubeurope.com/tags/GcnCycling" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>GcnCycling</span></a> <a href="https://pubeurope.com/tags/GlobalCyclingNetwork" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>GlobalCyclingNetwork</span></a> <a href="https://pubeurope.com/tags/n1" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>n1</span></a> <a href="https://pubeurope.com/tags/RoadBike" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>RoadBike</span></a> <a href="https://pubeurope.com/tags/SpeedLimit" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SpeedLimit</span></a> <a href="https://pubeurope.com/tags/sports" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>sports</span></a> <a href="https://pubeurope.com/tags/UK" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>UK</span></a> <a href="https://pubeurope.com/tags/UnitedKingdom" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>UnitedKingdom</span></a> <a href="https://pubeurope.com/tags/velo" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>velo</span></a> <a href="https://pubeurope.com/tags/%D5%82" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Ղ</span></a> <a href="https://pubeurope.com/tags/%E1%8B%BE" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ዾ</span></a> <a href="https://pubeurope.com/tags/%E0%AC%99" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ଙ</span></a> #಄ <a href="https://pubeurope.com/tags/%EA%97%A7" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ꗧ</span></a> #꤬ <a href="https://pubeurope.com/tags/%F0%91%A2%BB" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>𑢻</span></a></p>
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#n1
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The #antigenic #landscape of #N1 #neuraminidase in #human #influenza A virus strains isolated between 2009 and 2020, BioRxIV, https://www.biorxiv.org/content/10.1101/2024.12.10.627724v1
The resulting neuraminidase inhibition pattern revealed two antigenic groups that circulated in this period. A machine learning method identified K432E and I321V as key determinants of N1 neuraminidase antigenicity.
bioRxiv · The antigenic landscape of N1 neuraminidase in human influenza A virus strains isolated between 2009 and 2020The clinical burden caused by influenza can be mitigated by the prophylactic use of seasonal influenza vaccines. Their immunogen composition is revised biannually to optimally match the antigenic drift of the hemagglutinin of circulating influenza virus strains. Antibodies directed against the influenza neuraminidase also correlate with protection against influenza, yet the antigenic evolution of influenza neuraminidase remains underexplored. To evaluate the antigenic diversity of N1 neuraminidase, we generated a panel of immune sera directed against 17 N1 neuraminidases derived from human H1N1 strains that were isolated between 2009 and 2020 and determined its neuraminidase inhibition titers against a panel of 15 HxN1 viruses. The resulting neuraminidase inhibition pattern revealed two antigenic groups that circulated in this period. A machine learning method identified K432E and I321V as key determinants of N1 neuraminidase antigenicity.
### Competing Interest Statement
XS reports grants from Sanofi Vaccines. TUV, MGM, JH, BB, KR, GC, JZ, LH, EC, SR, PD, DT, YC are or were Sanofi employees and may hold shares and/or stock options in the company. This work was funded by Sanofi Vaccines.
A Computationally Optimized Broadly Reactive #Hemagglutinin and #Neuraminidase #Vaccine Boosts #Antibody-Secreting Cells and Induces a Robust #Serological Response, Preventing #Lung #Damage in a Pre-Immune #Model https://pubmed.ncbi.nlm.nih.gov/39066344/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1LGAx__djGAJ9poBzWGqPtjEbBDtz4ipSRRPUplmgHEyyF_Ihj&fc=None&ff=20240727133152&v=2.18.0.post9+e462414
... the combination of #H2, #H5, #H7, #N1, and #N2 #COBRA #antigens presents a potential for the formulation of a universal influenza virus vaccine.
PubMedA Computationally Optimized Broadly Reactive Hemagglutinin and Neuraminidase Vaccine Boosts Antibody-Secreting Cells and Induces a Robust Serological Response, Preventing Lung Damage in a Pre-Immune Model - PubMedThe hemagglutinin (HA) and neuraminidase (NA) surface proteins are the primary and secondary immune targets for most influenza vaccines. In this study, H2, H5, H7, N1, and N2 antigens designed by the computationally optimized broadly reactive antigen (COBRA) methodology were incorporated into an adj …
Newsletter subscribers check your inbox/spam folder for today's despatch, which contains this correction to our book, Ghost Signs: A London Story.
'X Doesn’t Mark the Spot: Revisiting an Islington Ghost Sign': https://ghostsigns.co.uk/2024/07/x-doesnt-mark-the-spot-revisiting-an-islington-ghost-sign/
Get the book here: https://ghostsigns.co.uk/publications/book/
Photo: @RoyReed
ALT
Replied to Ghostsigns (Sam Roberts)
Thank you to everyone that contributed to this discussion, which has corrected and deepened our understanding of this ghost sign: Nazalia it is!
I have written this up for the record here on the Ghostsigns blog: https://ghostsigns.co.uk/2024/07/x-doesnt-mark-the-spot-revisiting-an-islington-ghost-sign/
Thanks again @RoyReed @mass_driver @RayNewman @freetobeme @6b6279
X Doesn’t Mark the Spot: Revisiting an Islington Ghost Sign| Ghostsigns | Correcting the record for the Popham Street ghost sign previously thought to advertise X-Zalia, but now known to be for Nazalia. Photo: Roy Reed. · X Doesn’t Mark the Spot: Revisiting an Islington Ghost Sign |Correcting the record for the Popham Street ghost sign previously thought to advertise X-Zalia, but now known to be for Nazalia. Photo: Roy Reed.
X Doesn’t Mark the Spot: Revisiting an Islington Ghost Sign
https://ghostsigns.co.uk/2024/07/x-doesnt-mark-the-spot-revisiting-an-islington-ghost-sign/
Correcting the record for the Popham Street ghost sign previously thought to advertise X-Zalia, but now known to be for Nazalia. Photo: Roy Reed.
ALT
What's the missing word on this London ghost sign? @RoyReed recently got some better pictures than mine from the book, but we're stuck on the last line.
"___ Simple & Inexpensive"
[Rest in alt text]
I think I can see one of C/G/O as the first letter, and that it ends with an 'm' or 'rn', but none of the permutations are suggesting any fitting words.
Please reply with answers/guesses, and boost to get more eyes on it...
![Brick wall with a stucco panel set within a scalloped molded border. There is a fading painted sign on the panel which is more visible on the rightmost two thirds due to the leftmost third having a coat of blue paint over it. The visible lettering reads:
X-Zalia
Day & Night Cure for
Catarrh
& Colds in the Head
Prevents Influenza
[...] Simple & Inexpensive](https://files.mastodon.social/media_attachments/files/112/790/153/780/040/410/original/65f8bf132dc973f5.jpg "Brick wall with a stucco panel set within a scalloped molded border. There is a fading painted sign on the panel which is more visible on the rightmost two thirds due to the leftmost third having a coat of blue paint over it. The visible lettering reads:
X-Zalia
Day & Night Cure for
Catarrh
& Colds in the Head
Prevents Influenza
[...] Simple & Inexpensive")
ALT
ALT
#PlaneAlert ICAO: #A00001 Tail: #N1 Flt: #FLC1
Owner: #FederalAviationAdministration
Aircraft: #Gulfstream G-IV
2024/07/11 10:43:10
#GLF4 #Number1 #FAA #VanityPlate https://www.faa.gov
https://globe.adsbexchange.com/?icao=A00001&showTrace=2024-07-11&zoom=7&lat=41.22689&lon=-81.09720×tamp=1720708990
#planefence #adsb - docker:kx1t/planefence
【アニメで学ぶ】JLPT N1 文法 Day.78「ひとり〜のみならず」#JLPT #N1 #Grammar
https://youtu.be/wJiBusfmCkQ
#PlaneAlert ICAO: #A00001 Tail: #N1
Owner: #FederalAviationAdministration
Aircraft: #Gulfstream G-IV
2024/06/27 07:29:09
#GLF4 #Number1 #FAA #VanityPlate https://www.faa.gov
https://globe.adsbexchange.com/?icao=A00001&showTrace=2024-06-27&zoom=7&lat=39.09606&lon=-80.43445×tamp=1719487749
#planefence #adsb - docker:kx1t/planefence
#PlaneAlert ICAO: #A00001 Tail: #N1 Flt: #FLC1
Owner: #FederalAviationAdministration
Aircraft: #Gulfstream G-IV
2024/06/14 09:18:32
#GLF4 #Number1 #FAA #VanityPlate https://www.faa.gov
https://globe.adsbexchange.com/?icao=A00001&showTrace=2024-06-14&zoom=7&lat=40.21555&lon=-79.75731×tamp=1718371112
#planefence #adsb - docker:kx1t/planefence
#PlaneAlert ICAO: #A00001 Tail: #N1 Flt: #N1
Owner: #FederalAviationAdministration
Aircraft: #Gulfstream G-IV
2024/05/21 17:40:56
#GLF4 #Number1 #FAA #VanityPlate https://www.faa.gov
https://globe.adsbexchange.com/?icao=A00001&showTrace=2024-05-21&zoom=7&lat=38.03416&lon=-80.35622×tamp=1716327656
#planefence #adsb - docker:kx1t/planefence
#PlaneAlert ICAO: #A00001 Tail: #N1 Flt: #N1
Owner: #FederalAviationAdministration
Aircraft: #Gulfstream G-IV
2024/04/30 07:36:18
#GLF4 #Number1 #FAA #VanityPlate https://www.faa.gov
https://globe.adsbexchange.com/?icao=A00001&showTrace=2024-04-30&zoom=7&lat=38.65274&lon=-79.57141×tamp=1714476978
#planefence #adsb - docker:kx1t/planefence
