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#biology

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We are excited to welcome Aditi Deshpande to the Purvis Lab! This summer, Aditi will be continuing her research with support from a SURF grant, working alongside Dr. Tim Daugird to explore patterns in protein expression using quantitative approaches. Aditi is a sophomore at UNC majoring in Quantitative Biology and Applied Mathematics, with a minor in Data Science. Welcome, Aditi—we’re thrilled to have you on the team! 👋

Physicist revisits the computational limits of life and Schrödinger's essential question in the era of quantum computing

phys.org/news/2025-03-physicis

> More than 80 years ago, Erwin Schrödinger, a theoretical physicist steeped in the philosophy of Schopenhauer and the Upanishads, delivered a series of public lectures at Trinity College, Dublin, which eventually came to be published in 1944 under the title "What is Life?"

phys.orgPhysicist revisits the computational limits of life and Schrödinger's essential question in the era of quantum computingMore than 80 years ago, Erwin Schrödinger, a theoretical physicist steeped in the philosophy of Schopenhauer and the Upanishads, delivered a series of public lectures at Trinity College, Dublin, which eventually came to be published in 1944 under the title "What is Life?"

Zwitterionic Phospholipids Enhance mRNA Delivery Efficiency

Summary: Researchers at Hokkaido University introduce a novel class of zwitterionic phospholipids, enhancing mRNA therapy delivery by overcoming endosomal escape challenges. The DOPE-Cx variant boosts mRNA expression and rapid clearance, reducing toxicity, promising advancements in RNA therapeutics.

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https://biohackers.media/zwitterionic-phospholipids-enhance-mrna-delivery-efficiency

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Biohackers Media · Zwitterionic Phospholipids Enhance mRNA Delivery EfficiencyInnovative zwitterionic phospholipids enhance mRNA delivery, overcoming endosomal escape with DOPE-Cx for therapeutic breakthroughs.

Impact of Oral Contraceptives on Hormone Levels

Summary: Recent research in Science Advances reveals that oral contraceptives and smoking significantly affect steroid hormone levels in adults, a vital step in understanding hormone-related health influences. The study involved nearly 1,000 healthy individuals, examining lifestyle and genetic factors on hormone variability.

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https://biohackers.media/impact-of-oral-contraceptives-on-hormone-levels

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Biohackers Media · Impact of Oral Contraceptives on Hormone LevelsOral contraceptives and smoking significantly impact steroid hormone levels, highlighting crucial health influences in a recent study.

Innovative Optic Tract Repair Model Enhances CNS Recovery

Summary: The groundbreaking study by Prof. Liu Kai's team explores innovative CNS optic tract injury models, highlighting key strategies for axonal regeneration and synaptic enhancement with significant implications for repairing neural injuries.

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https://biohackers.media/innovative-optic-tract-repair-model-enhances-cns-recovery

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Biohackers Media · Innovative Optic Tract Repair Model Enhances CNS RecoveryInnovative CNS model enhances optic tract injury recovery by axonal regeneration and synaptic enhancement via targeted interventions.

Toward a Nonbinary Model of Gender/Sex Traits
Renata Ziemińska (2022) Hypatia

"The nonbinary category ... is a third category of traits, not of people. Under the nonbinary model, the basic gender concepts do not disappear. S is a woman if S is a human being with enough female traits, and the trait of having self-determined female gender identity is sufficient but not necessary."

cambridge.org/core/journals/hy

DNA-LNP Vaccines: Revolutionizing Immunization Strategies

Summary: Scientists at The Wistar Institute have developed a DNA vaccine using plasmid DNA and lipid nanoparticles, enhancing efficacy and stability. The research, published in Cell Reports Medicine, highlights improvements in particle size, immune response, and adaptive immunity, advancing vaccination technology.

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https://biohackers.media/dna-lnp-vaccines-revolutionizing-immunization-strategies

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Biohackers Media · DNA-LNP Vaccines: Revolutionizing Immunization StrategiesWistar Institute advances DNA-LNP vaccine technology, enhancing stability and immune response, promising next-gen vaccination solutions.

Sex Influences Hearing Sensitivity More Than Age

Summary: Recent findings from CRBE reveal that women have an average 2 decibel greater hearing sensitivity than men, highlighting significant sex-based differences. Factors like environment and urban versus rural setting also affect hearing, with forested areas enhancing sensitivity.

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https://biohackers.media/sex-influences-hearing-sensitivity-more-than-age

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Biohackers Media · Sex Influences Hearing Sensitivity More Than AgeSex, not age, significantly impacts hearing sensitivity. Women show greater sensitivity than men across diverse global populations.

Enhancing Microscopic Swimming: Drug Delivery Potential

Summary: Recent research by Loughborough University and the Indian Institute of Science reveals bacteria's enhanced swimming speed through collective movement, paving the way for microscopic robots in drug delivery, potentially transforming medical treatments.

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https://biohackers.media/enhancing-microscopic-swimming-drug-delivery-potential

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Biohackers Media · Enhancing Microscopic Swimming: Drug Delivery PotentialMicroswimmers enhance speed via collective movement, paving the way for innovative drug delivery; key study insights revealed by global researchers.

Sex Differences Drive Hearing Sensitivity, Study Finds

Summary: Research in Scientific Reports indicates sex primarily influences hearing sensitivity, with women exhibiting better hearing than men. Studies on 450 individuals across diverse populations showed women have two decibels more sensitive hearing, highlighting biological and environmental factors.

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https://biohackers.media/sex-differences-drive-hearing-sensitivity-study-finds

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Biohackers Media · Sex Differences Drive Hearing Sensitivity, Study FindsStudy shows women have better hearing; environmental factors also affect sensitivity, highlighting sex as a primary influence.